The natural history of human papillomavirus infections of the mucosal epithelia
Top Cited Papers
- 15 June 2010
- Vol. 118 (6-7) , 422-449
- https://doi.org/10.1111/j.1600-0463.2010.02625.x
Abstract
Human papillomaviruses (HPVs), members of a very large family of small DNA viruses, cause both benign papillomas and malignant tumors. While most research on these viruses over the past 30 years has focused on their oncogenic properties in the genital tract, they also play an important role in diseases of the upper aerodigestive tract. Rapidly accelerating advances in knowledge have increased our understanding of the biology of these viruses and this knowledge, in turn, is being applied to new approaches to prevent, diagnose, and treat HPV-induced diseases. In this introductory article, we provide an overview of the structure and life cycle of the mucosal HPVs and their interactions with their target tissues and cells. Finally, we provide our thoughts about treatments for HPV-induced diseases, present and future.This publication has 146 references indexed in Scilit:
- The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface bindingProceedings of the National Academy of Sciences, 2009
- Oncogenic activities of human papillomavirusesPublished by Elsevier ,2009
- Robust production and passaging of infectious HPV in squamous epithelium of primary human keratinocytesGenes & Development, 2009
- Papillomavirus E6 proteinsVirology, 2008
- Casein Kinase II Motif-Dependent Phosphorylation of Human Papillomavirus E7 Protein Promotes p130 Degradation and S-Phase Induction in Differentiated Human KeratinocytesJournal of Virology, 2008
- Remodeling of the Human Papillomavirus Type 11 Replication Origin into Discrete Nucleoprotein Particles and Looped Structures by the E2 ProteinJournal of Molecular Biology, 2008
- Human papillomavirus DNA testing for the detection of cervical intraepithelial neoplasia grade 3 and cancer: 5-year follow-up of a randomised controlled implementation trialThe Lancet, 2007
- A New E6/P63 Pathway, Together with a Strong E7/E2F Mitotic Pathway, Modulates the Transcriptome in Cervical Cancer CellsJournal of Virology, 2007
- Papillomaviruses and cancer: from basic studies to clinical applicationNature Reviews Cancer, 2002
- Integrated Human Papillomavirus Type 16 Is Frequently Found in Cervical Cancer Precursors as Demonstrated by a Novel Quantitative Real-Time PCR TechniqueJournal of Clinical Microbiology, 2002