Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit
- 1 September 1996
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 6 (18) , 2207-2210
- https://doi.org/10.1016/0960-894x(96)00401-5
Abstract
No abstract availableThis publication has 28 references indexed in Scilit:
- CC‐1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic StudiesAngewandte Chemie International Edition in English, 1996
- Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry.CHEMICAL & PHARMACEUTICAL BULLETIN, 1995
- (+)- and ent-(-)-Duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA Alkylation Properties.Alkylation Site Models That Accommodate the Offset AT-Rich Adenine N3 Alkylation Selectivity of the Enantiomeric AgentsJournal of the American Chemical Society, 1994
- DNA alkylation properties of the duocarmycins: (+)-duocarmycin A, epi-(+)-duocarmycin A, ent-(−)-duocarmycin A and epi,ent-(−)-duocarmycin ABioorganic & Medicinal Chemistry Letters, 1992
- Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophoreThe Journal of Organic Chemistry, 1990
- Sequence specificity of DNA alkylation by the unnatural enantiomer of CC-1065 and its synthetic analogsJournal of the American Chemical Society, 1990
- Synthesis and evaluation of aborted and extended CC-1065 functional analogs: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of key partial structures and definition of an additional functional role of the CC-1065 central and right-hand subunitsJournal of the American Chemical Society, 1990
- Total synthesis and evaluation of (.+-.)-N-(tert-butoxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunitJournal of the American Chemical Society, 1989
- Sequence selectivity of DNA covalent modificationChemical Research in Toxicology, 1988
- Molecular basis for sequence-specific DNA alkylation by CC-1065Biochemistry, 1988