Enantioselective reaction of diethylzinc with arenecarbaldehydes in the presence of ephedrine derivatives
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 2731-2735
- https://doi.org/10.1039/p19910002731
Abstract
The reaction of diethylzinc with a range of arenecarbaldehydes has been catalysed by N-alkyl ephedrines to give 1-arylpropan-1-ols with good to excellent optical yields. The enantioselectivity of the reaction was substantially improved by the use of a 4 molar excess of the organozinc reagent.Keywords
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