Bruceanols D, E, and F. Three New Cytotoxic Quassinoids from Brucea antidysenterica
- 1 December 1993
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 56 (12) , 2091-2097
- https://doi.org/10.1021/np50102a010
Abstract
Three new quassinoids, bruceanols D [1], E [2], and F [3], were isolated from Brucea antidysenterica, and their structures were elucidated by spectral evidence and chemical transformation. All of these compounds exhibited cytotoxicity against five human tumor cell lines, malignant melanoma (RPMI-7951), lung carcinoma (A-549), ileocecal adenocarcinoma (HCT-8), epidermoid carcinoma of the nasopharynx (KB), and medulloblastoma (TE-671), and against murine lymphocytic leukemia (P-388).Keywords
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