AN AUTOPSY CASE OF CREUTZFELDT‐JAKOB DISEASE WITH KURU‐LIKE NEUROPATHOLOGICAL CHANGES
- 1 March 1977
- journal article
- research article
- Published by Wiley in Acta Pathologica Japonica
- Vol. 27 (2) , 231-238
- https://doi.org/10.1111/j.1440-1827.1977.tb01872.x
Abstract
An autopsy case of Creutzfeldt‐Jakob disease with Kuru‐llke neuropatho‐logical changes which revealed clinically extrapyramidal, pyramidal and psychic symptoms is presented in this report. On microscopic examination, status spongiosus, neuronal degeneration, proliferation of hypertrophic astrocytes and numerous plaques were observed in the cerebrum and cerebellum accompanied with widespread demyelinization. These plaques which suggested Kuru plaques measuring 10 to 60 μ were strongly PAS positive and had a dense central core surrounded by a halo of fine radially arranged fibrils. As for the relationship between Creutzfeldt‐Jakob disease and Kuru, the significance of these morphological changes is discussedThis publication has 19 references indexed in Scilit:
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