Alterations in the Expression of Transcription Factors and the Reduced Folate Carrier as a Novel Mechanism of Antifolate Resistance in Human Leukemia Cells
Open Access
- 1 March 2003
- journal article
- Published by Elsevier
- Vol. 278 (11) , 8935-8941
- https://doi.org/10.1074/jbc.m209578200
Abstract
No abstract availableKeywords
This publication has 16 references indexed in Scilit:
- Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell linesBiochemical Journal, 2002
- Methylation-dependent Silencing of the Reduced Folate Carrier Gene in Inherently Methotrexate-resistant Human Breast Cancer CellsJournal of Biological Chemistry, 2001
- The Basal Promoters for the Human Reduced Folate Carrier Gene Are Regulated by a GC-box and a cAMP-response Element/AP-1-like ElementJournal of Biological Chemistry, 2001
- mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR methodLeukemia, 2000
- Clustering of Mutations in the First Transmembrane Domain of the Human Reduced Folate Carrier in GW1843U89-resistant Leukemia Cells with Impaired Antifolate Transport and Augmented Folate UptakeJournal of Biological Chemistry, 2000
- AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferaseInvestigational New Drugs, 1996
- Competition of Hydrophobic Peptides, Cytotoxic Drugs, and Chemosensitizers on a Common P-glycoprotein Pharmacophore as Revealed by Its ATPase ActivityJournal of Biological Chemistry, 1996
- Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cellsNucleic Acids Research, 1989
- Sequence-specific interactions of nuclear factors with the insulin gene enhancerCell, 1986
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976