Network-based support vector machine for classification of microarray samples
Open Access
- 30 January 2009
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 10 (S1) , S21
- https://doi.org/10.1186/1471-2105-10-s1-s21
Abstract
The importance of network-based approach to identifying biological markers for diagnostic classification and prognostic assessment in the context of microarray data has been increasingly recognized. To our knowledge, there have been few, if any, statistical tools that explicitly incorporate the prior information of gene networks into classifier building. The main idea of this paper is to take full advantage of the biological observation that neighboring genes in a network tend to function together in biological processes and to embed this information into a formal statistical framework.Keywords
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