Calcium and monoamine regulation: role of vitamin D nutrition

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Abstract
The mechanism of vitamin D participation in the processes of monoamine regulation was studied. Central and peripheral endogenous norepinephrine [NE] levels were compared in vitamin D deficient rats, in preventive vitamin D3 (1 IU/day) administered rats, and in lactose (20% of the diet) administered rats, lactose being known to increase intestinal absorption of Ca. Vitamin D deficiency resulted in a significant decrease in endogenous NE. The decrease was of variable magnitude according to the considered organs. The adrenal dopamine level was less in vitamin D deficient rats than in rats given vitamin D in preventive treatment. It remained unaffected in the brain. In the absence of vitamin D dietary lactose restored blood Ca and endogenous NE levels in all the tissues, except in the liver. It appears that the decrease in NE storage in vitamin D deficient rats resulted from a lack of Ca rather than from the absence of vitamin D.

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