Is resistance to phospholipase important for the gastric mucosal protective capacity of exogenous phosphatidylcholine?

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Abstract
Objective. The protective capacities of phospholipase-resistant phosphatidylcholine and digalactosyldiacylglycerol against acute and chronic gastric mucosal lesions were evaluated in rats, and compared with those of misoprostol, sucralfate and saturated phosphatidylcholine. Methods. Acute corporal erosions were induced in fasted rats by intragastric administration of absolute ethanol. Chronic antral ulcers were induced in re-fed rats (rats were allowed access to food pellets for 1 h after a 24-h fast) by subcutaneous injection of indomethacin. Protective solutions in different concentrations were given intragastrically, in single or repeated doses. Results. Phospholipase-resistant phosphatidylcholine protected against ethanol-induced acute lesions, with a capacity comparable to those of misoprostol and sucralfate, and superior to that of saturated phosphatidylcholine. In the chronic lesion model, the initial protective capacity of phospholipase-resistant phosphatidylcholine was superior to those of misoprostol, sucralfate, saturated phosphatidylcholine and digalactosyldiacylglycerol. After 72 h, the protective capacity of misoprostol was superior to the incomplete and temporary effect of sucralfate. Quinacrine, a phospholipase A2 inhibitor, aggravated chronic antral ulcers and also induced haemorrhagic damage of the gastric corpus. Conclusion. Exogenous phosphatidylcholine seems to protect the gastric mucosa regardless of its susceptibility to phospholipase A2 action. Digalactosyldiacylglycerol also exerted a gastroprotective effect.

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