THE CONCENTRATION OF PEROXIDASE IN NORMAL AND ADENOMATOUS HUMAN THYROID TISSUE WITH SPECIAL REFERENCE TO PATIENTS WITH PENDRED'S SYNDROME

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Abstract
The peroxidase content in the thyroids from two patients with Pendred's syndrome (abnormal discharge of iodide from the thyroid after perchlorate administration, congenital deafness and sporadic goitre) was investigated and compared to the content in 11 patients with normal thyroids, 22 patients with adenomatous goitres and 12 patients with diffuse toxic goitres. The results indicate that the peroxidase contents in the patients with Pendred's syndrome are not decreased as compared to normal or nodular thyroid tissue. The results are discussed with regard to the cause of an intrathyroidal iodide organification defect. It is suggested that patients with Pendred's syndrome may have a defective hydrogen peroxide producing system.

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