Cortisone Effect on Antibody Levels in Rabbits Simultaneously Immunized with Serum Albumin and Sheep Cells.

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Abstract
In rabbits simultaneously immunized with antigens vastly different in size of particle (Bovine serum albumin and sheep cell stroma) cortisone suppressed antibody formation to the soluble antigen but not to the particulate antigen. Antibody was measured by both serologic and quantitative N methods. In the cortisone-treated animals antibody levels to stroma were comparable to those in the untreated rabbits. In animals immunized with whole sheep cells and serum albumin, antibody levels to sheep cells in the cortisone-treated and control groups were similar. The data are interpreted to indicate that the mechanism of cortisone suppression of antibody is related to particle size of the immunizing antigen.

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