A New Simple Route To N-Substituted 2-Aminoethylphosphonic Acids
- 1 July 1998
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 28 (14) , 2659-2664
- https://doi.org/10.1080/00397919808004835
Abstract
2-Aminoethylphosphonic acid (AEPA) and its N-substituted compounds were prepared by one step reaction using 2-chloroethylphosphonic acid with ammonia and amines (H2NMe, HNMeMe, HNEtEt, H2NPr-n, H2NCH2ph, H2NCH2CH2NH2 and H2N(C=NH)NH2 in a dilute alkaline solution below 20 °C with simple work-up and easy purification. The reaction was accelerated by catalytic amount of potassium iodide. The yield for the reaction products were 35.6 to 48.6% for the KI absence and 78.2 to 88.0% for the KI presence.Keywords
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