HALOGEN-SUBSTITUTED OESTROGENS RELATED TO TRIPHENYLETHYLENE

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Abstract
Various derivatives of triphenylchloroethylene and triphenylbromoethylene have been examined for oestrogenic activity during the past decade, notably those compounds substituted with p-alkoxy groups. In general, they are not very potent oestrogens, but combine long duration of action with sufficient oestrogenic activity to make them of laboratory and clinical interest. They are particularly interesting, however, in that they form a series in which halogen substitution enhances the oestrogenic activity of the molecule. Thus, triphenylchloroethylene was reported by Robson, Schönberg & Fahim [1938] to have 20 times the activity of triphenylethylene. This effect of halogen substitution is not seen in the other series of synthetic oestrogens so far studied. A further peculiarity of triphenylchloroethylene was remarked by the present author [Emmens, 1941], who found that in contrast to triphenylethylene it has the properties of a true oestrogen, in that the median effective dose (m.e.d.) required by intravaginal application is a small

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