PROTECTIVE ANTIGENS IN FRACTIONS OF ADULT NEMATOSPIROIDES DUBIUS
- 1 August 1986
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 64 (4) , 335-343
- https://doi.org/10.1038/icb.1986.35
Abstract
Adult Nematospiroides dubius crude soluble homogenate consistently produced five fractions (Fl-5) after filtration through Sephadex G-200 with molecular weights of >300,000, 240,000, 83,000, 31,000 and < 10,000. The high molecular weight Fl and F2 reacted strongly with serum from previously infected mice in ELISA. Protective immunity was associated with Fl N. dubius immunogens (molecular weight > 300,000). Immunization with smaller molecular weight fractions also reduced worm recoveries following challenge infections but to a lesser extent.Keywords
This publication has 1 reference indexed in Scilit:
- The gel-filtration behaviour of proteins related to their molecular weights over a wide rangeBiochemical Journal, 1965