Evidence for an HLA-Linked Resistance Gene in Buerger's Disease
- 11 December 2008
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 14 (2) , 169-173
- https://doi.org/10.1111/j.1399-0039.1979.tb00835.x
Abstract
The incidence of Thromboangiitis Obliterans in brothers and the high prevalence in some ethnic groups have led us to investigate the histocompatibility HLA-A, B and DR antigens of 46 Buerger's disease patients. The main result indicates a marked decreased freqeuncy of the B12 antigen: 2.2% vs 28% in controls. Our study suggests that Buerger's disease is, on the basis of HLA antigens, a distinct immunogenetic entity and not a particular form of arteriosclerosis. Moreover, this disorder may represent a clue to the existence of resistance genes linked to HLA.Keywords
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