Aryl Hydrocarbon Hydroxylase Inducibility in Laryngeal Carcinoma
- 1 March 1978
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 104 (3) , 151-152
- https://doi.org/10.1001/archotol.1978.00790030037008
Abstract
• The chief carcinogens of tobacco smoke—the polycyclic aromatic hydrocarbons—must be activated in the cells to exert their carcinogenic effect. This activation is carried out by the enzyme system aryl hydrocarbon hydroxylase (AHH). Mitogen-stimulated, human lymphocyte studies of AHH activity indicate wide individual variation, which is under strict genetic control. The venous blood samples from 90 patients with a laryngeal carcinoma were assayed, and a significant overrepresentation of patients with genetically high AHH inducibility was demonstrated. Our results suggest the possibility of identifying those tobacco users at higher genetic risk for developing carcinoma of the larynx. (Arch Otolaryngol 104:151-152, 1978)This publication has 3 references indexed in Scilit:
- Chemical CarcinogenesisAnnual Review of Biochemistry, 1975
- Aryl Hydrocarbon Hydroxylase Induction in Human LeukocytesScience, 1972
- Epoxides as microsomal metabolites of polycyclic hydrocarbonsFEBS Letters, 1971