Reduction of Respiratory Tract Binding of Benzo[a]pyrene in Mice by Immunization2
- 1 November 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 61 (5) , 1347-1349
- https://doi.org/10.1093/jnci/61.5.1347
Abstract
Male inbred A/J mice immunized by combined ip and intranasal administration of a bovine serum albumin conjugate of 5-fluoro-12-methylbenzanthryl-7-acetlc acid developed tracheal antibodies capable of binding the carcinogen benzo[ a]pyrene (BP). Immunized mice administered 92 ng of [3H]BP intranasally exhibited a one-third reduction in BP content In respiratory tract tissues (nose and trachea) when compared with control mice 20 hours after BP administration.Keywords
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