THE DOMINANCE OF STREPTOMYCIN SENSITIVITY RE-EXAMINED
- 1 March 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 62 (3) , 979-985
- https://doi.org/10.1073/pnas.62.3.979
Abstract
Several aspects of the strA phenotype were studied in strains of Escherichia coli diploid in the strA chromosomal region. It was found that alleles causing different levels of interference with amber suppression can complement each other, the less restrictive effects being predominant. The sensitive strA + allele determines two responses to streptomycin: a dominant effect consisting of a sudden, complete, but reversible inhibition of growth, and a recessive effect manifested as cell killing. Both restriction of suppression and inhibition of growth reflect ribosomal involvement in translation.Keywords
This publication has 12 references indexed in Scilit:
- A ribosomal ambiguity mutationJournal of Molecular Biology, 1969
- Ribosomes from Escherichia coli merodiploids heterozygous for resistance to streptomycin and to spectinomycinJournal of Molecular Biology, 1968
- Mechanism of action of streptomycin in E. coli: interruption of the ribosome cycle at the initiation of protein synthesis.Proceedings of the National Academy of Sciences, 1968
- Formation of merodiploids in matings with a class of Rec- recipient strains of Escherichia coli K12.Proceedings of the National Academy of Sciences, 1968
- Streptomycin Resistance Mutation in Escherichia coli : Altered Ribosomal ProteinScience, 1968
- Phenotypic Masking and Streptomycin DependenceScience, 1967
- A mutation suppressing streptomycin dependenceJournal of Molecular Biology, 1967
- Ribosomal AmbiguityCold Spring Harbor Symposia on Quantitative Biology, 1966
- High pleiotropy of streptomycin mutations in Escherichia coliBiochemical and Biophysical Research Communications, 1964
- Genetics of Regulation of Enzyme Synthesis in the Arginine Biosynthetic Pathway of Escherichia coliCold Spring Harbor Symposia on Quantitative Biology, 1961