Inhibitory Effect of Calcium Antagonists on Histamine Release from Human Leukocytes.
- 1 May 1983
- Vol. 38 (4) , 233-237
- https://doi.org/10.1111/j.1398-9995.1983.tb01616.x
Abstract
A study was made of the influence of calcium antagonists on human basophil histamine release induced in vitro by specific antigen, anti-IgE or the calcium ionophore A23187. Both verapamil, nifedipine, and nimodipine were found to inhibit the release, and a similar effect was also observed after peroral administration of verapamil and nifedipine. The inhibitory effect of the drugs on histamine release seems to depend on interaction with calcium at different sites. The anti-allergic effect might explain the improvement found with calcium antagonists in exercise-induced asthma.Keywords
This publication has 13 references indexed in Scilit:
- Calcium channels: direct identification with radioligand binding studiesTrends in Pharmacological Sciences, 1982
- A calcium antagonist, nifedipine, modifies exercise-induced asthma.Thorax, 1981
- The effect of calcium antagonist, nifedipine in exercise‐induced asthmaClinical and Experimental Allergy, 1981
- Histamine release from rat mast cells sensitized with mouse antiserumInflammation Research, 1981
- Calcium antagonists in exercise-induced asthma.BMJ, 1981
- Analysis of triggering events in mast cells for immunoglobulin E-mediated histamine releaseJournal of Allergy and Clinical Immunology, 1981
- Desensitization of ionophore A23187 responses by muscarinic receptor stimulation in intestinal smooth muscleBiochemical Pharmacology, 1981
- Antiasthmatic Drug Therapy and Calcium Ions: Review of Pathogenesis and Role of CalciumJournal of Pharmaceutical Sciences, 1980
- A SIMPLIFIED METHOD FOR MEASURING BASOPHIL HISTAMINE RELEASE AND BLOCKING ANTIBODIES IN HAY FEVER PATIENTS. BASOPHIL HISTAMINE CONTENT AND CELL PRESERVATIONAllergy, 1977
- Basophil leucocyte separation from human peripheral blood: a technique for their isolation in high purity and high yieldClinical and Experimental Allergy, 1972