Increased Inulin Absorption from the Gat Stomach Exposed to Acetylsalicylic Acid

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Abstract
Polydisperse14C‐inulin was absorbed from the stomach of the cat when 15 mM acetylsalicylic acid, mainly in the unionized form, in isotonic NaCl solution, was also present in the lumen. The absorbed inulin was rapidly excreted and accumulated in the urine in sufficient quantities for molecular weight distribution analysis. The latter showed that about 95 percent of the urinary inulin had a molecular weight greater than 2000 and that only moderate molecular sieving of the instilled inulin (weight average molecular weight 5200) occurred. This means very probably that larger molecular species than tested here could be absorbed from the stomach. The instillation of14C‐inulin in acetylsalicylic acid‐free isotonic NaCl, however, also resulted in a smaller but significant inulin absorption. The latter was further considerably reduced if the inulin was not added together with the isotonic saline, but later (20 min) in a small liquid volume. This suggests that mere distension of the stomach causes a temporary increase of the permeability which, however, is much smaller than that after acetylsalicylic acid. It may be relevant that acetylsalicylic acid was found here to increase gastric absorption of saccharide molecules of a size earlier reported to be sufficiently large to evoke immune reactions.