Enhanced intestinal glucose and alanine transport in cystic fibrosis.
Open Access
- 1 July 1990
- Vol. 31 (7) , 817-820
- https://doi.org/10.1136/gut.31.7.817
Abstract
The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na(+)-linked nutrient transport is enhanced in cystic fibrosis.This publication has 14 references indexed in Scilit:
- Failure to induce secretion in jejunal biopsies from children with cystic fibrosis.Gut, 1988
- Altered intestinal chloride transport in cystic fibrosisThe FASEB Journal, 1988
- ABSENCE OF SECRETORY RESPONSE IN JEJUNAL BIOPSY SAMPLES FROM CHILDREN WITH CYSTIC FIBROSISThe Lancet, 1987
- ABSENCE OF SECRETORY RESPONSE IN JEJUNAL BIOPSY SAMPLES FROM CHILDREN WITH CYSTIC FIBROSISThe Lancet, 1987
- Changes in the apparent chloride permeability of Necturus enterocytes during the sodium-coupled transport of alanineBiochimica et Biophysica Acta (BBA) - Biomembranes, 1987
- RELATION BETWEEN MICROVILLI MEMBRANE-POTENTIAL AND GLUCOSE-TRANSPORT CAPACITY OF RAT SMALL-INTESTINE1987
- The Role of the Small Intestine in Cystic Fibrosis PatientsActa Paediatrica, 1985
- Enhanced glucose absorption in the jejunum of patients with cystic fibrosisGastroenterology, 1985
- Small intestinal absorption of amino acids and a dipeptide in pancreatic insufficiency.Gut, 1983
- Streaming potentials in the rat small intestineThe Journal of Physiology, 1966