COMPARATIVE EFFICACY OF VITAMIN D PREPARATIONS IN PROPHYLACTIC TREATMENT OF PREMATURE INFANTS

1 January 1949

journal article
research article
Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine

Vol. 77 (1) , 1-14
https://doi.org/10.1001/archpedi.1949.02030040008001

Abstract

THE NEED of the premature infant for vitamin D has generally been regarded as greater than that of the full term infant. It has been the common practice¹ to administer high doses of a concentrate of vitamin D as a measure of safety. Shelling and Hopper² and Gleich³ suggested daily doses of 1,000 to 2,000 U. S. P. units. Indeed several reports⁴ indicated that rickets may develop in premature infants even when 2,700 to 5,000 units of vitamin D is administered daily. Such dosages are in great contrast to that of 400 units which Stearns, Jeans and Vandercar⁵ reported sufficient in full term infants for normal growth and prevention of rickets. The recent discovery of vitamin D₃, formed by irradiation of 7-dehydrocholesterol, and the recognition of the probable presence of this compound in cod liver oil and in the skin of rats and swine

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