In vitro effects of vitamin D3 on the phospholipids of isolated renal brush border membranes

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Abstract
Summary A model system is described in which cholecalciferol (vitamin D3) is incorporated into phosphatidylcholine liposomes and then the liposomes are incubatedin vitro with isolated renal brush border membrane vesicles. The incubation results in an alteration of the phospholipid composition, the fluidity, and the transport properties of the membrane. The findings provide evidence consistent with the hypothesis that vitamin D3 and metabolites modify membrane structure and function by “liponomic regulation”.