The KRAB Domain of Zinc Finger Gene ZNF268: a Potential Transcriptional Repressor
Open Access
- 1 March 2003
- journal article
- Published by Wiley in IUBMB Life
- Vol. 55 (3) , 127-131
- https://doi.org/10.1080/1521654031000110208
Abstract
Nearly one‐third of Krupple‐type C2H2 zinc finger proteins have a krupple‐associated box (KRAB) domain, which may act as a transcriptional repressor. ZNF268, which was novelty isolated from early human embryo, is a typical krupple‐type C2H2 zinc finger protein with a conserved KRAB domain. In this report, the KRAB domain of ZNF268 is identified to localize in the nucleus and has transcriptional repressor activity. IUBMB Life, 55: 127‐131, 2003Keywords
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