Effects of Lilly 110140 (fluoxetine) on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in the mouse
- 1 November 1980
- journal article
- Published by Springer Nature in Psychopharmacology
- Vol. 71 (2) , 143-146
- https://doi.org/10.1007/bf00434402
Abstract
The effects of Lilly 110140 (fluoxetine) injected IP on self-stimulation behavior triggered in the dorsal and ventral regions of the lateral hypothalamus were studied in C57BL/6 mice strain. Lilly 110140 inhibits serotonin reuptake. It depresses dorsal self-stimulation at a low dose (5 mg/kg) and improves ventral self-stimulation at a high dose (20 mg/kg). The changes brought about by the injection of the 5 mg/kg dose support the proposed inhibitory role of serotonin on self-stimulation and also suggest that the fibers communicating with certain serotonergic neurons are localized primarily in the dorsal region of the lateral hypothalamus.Keywords
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