A strategy for the contrast enhancement of malignant tumors using dynamic computed tomography and intravascular pharmacokinetics.

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Abstract
Sequential dynamic computed tomographic (CT) body scans were performed during administration of diatrizoate (intravascular bolus and infusion) in 18 cancer patients, 3 patients with cysts and 4 rabbits with V2 carcinoma. The best diagnostic images occurred soon after the bolus was given (within 60-90 s). Tumors and normal tissue became isodense with drip infusions and on delayed scans. Tumors had increased CT numbers (mean, 29.2; range, 11-64); unchanging CT numbers helped identify cysts. Three cancer patients were scanned after i.v. and intra-arterial injection of contrast media. Contrast enhancement and cancer CT numbers were highest after intra-arterial administration.