THE STABILITY OF CARBOPLATIN, DIAMORPHINE, 5-FLUOROURACIL AND MITOZANTRONE INFUSIONS IN AN AMBULATORY PUMP UNDER STORAGE AND PROLONGED ‘IN-USE’ CONDITIONS

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Abstract
Drug infusions can be exposed for prolonged periods to ‘in-use’ conditions where the temperature of an infusion in a holster-worn infusion pump may reach 37°C. In this study, the stability of three cytotoxic drug infusions (carboplatin, 5-fluorouracil and mitozantrone) and one analgesic infusion (diamorphine HCl) was determined in Parker Micropump medication reservoirs under refrigerated storage and prolonged in-use conditions. The stability of the three cytotoxic drug infusions was unaffected by 14 days storage at either 4 or 37°C. The diamorphine HCl infusion was stable over 14 days storage at 4°C but under in-use conditions at 37°C, drug degradation became significant (> 5%) if storage exceeded 7 days.