A Model for the Effect of Inhalation Device Flow Resistance on the Peak Inspiratory Flow Rate and Its Application in Pharmaceutical Testing
- 1 January 1994
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Aerosol Medicine
- Vol. 7 (2) , 201-204
- https://doi.org/10.1089/jam.1994.7.201
Abstract
An empirical relation between the peak inspiratory flow through a device and the flow resistance of the device has been developed using results from healthy subjects and verified to a limited extent using data from asthmatic patients. The empirical relation can be used to predict the change in peak inspiratory flow resulting from a change in flow resistance. Matching flow rates, representing equal inspiratory force, may thus be calculated for different inhalation devices. The fine particle dose generated by a variety of commercial powder inhalers was tested in-vitro at flow rates representing, for each device, a weak, a medium and a forceful inspiration. It was found that both the level of the fine particle dose and its flow rate dependence varied for the products.Keywords
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