Direct comparison of theoretical and experimental melting profiles for RFII ΦX174 DNA
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 271 (5640) , 28-31
- https://doi.org/10.1038/271028a0
Abstract
The determination of the complete nucleotide sequence for .vphi.X174 DNA made it possible for the 1st time to compare directly theoretical and experimental DNA melting profiles. The comparison shows that the theory predicts the observed shape of the differential melting curve surprisingly well. Calculation of the denaturation maps allows the peaks on the curve to be correlated with cooperative melting out of concrete regions on the sequence of nucleotides.Keywords
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