Insulin-Induced Augmentation of Lymphocyte-Mediated Cytotoxicity
- 28 March 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 187 (4182) , 1206-1208
- https://doi.org/10.1126/science.163492
Abstract
Physiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure target cells. The effect of insulin closely resembles the action of cholinomimetics and guanosine 3',5'-monophosphate upon this system. Since both insulin and cholinomimetics elevate intracellular concentrations of guanosine 3',5'-monophosphate, a common mode of action is suggested.Keywords
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