ORIGINAL ARTICLE: Two Different Homing Pathways Involving Integrin β7 and E‐selectin Significantly Influence Trafficking of CD4 Cells to the Genital Tract Following Chlamydia muridarum Infection
- 6 May 2009
- journal article
- Published by Wiley in American Journal of Reproductive Immunology
- Vol. 61 (6) , 438-445
- https://doi.org/10.1111/j.1600-0897.2009.00704.x
Abstract
Problem Chlamydia trachomatis causes STI and reproductive dysfunction worldwide which is not preventable with antibiotics. Identifying a population of endocervical T cells to target in vaccine development would enhance efficacy. Method of study Trafficking of murine CD4+ lymphocytes to Chlamydia muridarum infected genital tract (GT) tissue in vivo was measured using adoptive transfer studies of fluorescent CD4+ T cells from integrin β7−/− mice or mice which lack E‐selectin on endothelial cells. Results Murine in vivo migration studies showed that lack of α4β7 or E‐selectin significantly reduced trafficking of CD4 T cells to the GT of mice infected with C. muridarum. Conclusion CD4+ T cells use at least two different adhesive mechanisms involving an integrin of the mucosal homing pathway and selectin pathway to accumulate in the GT during C. muridarum infection.Keywords
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