9-[(10-(aden-9-yl)-4,8-diazadecyl)amino]-6-chloro-2-methoxy-acridine incises DNA at apurinic sites
Open Access
- 1 January 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (6) , 2691-2703
- https://doi.org/10.1093/nar/16.6.2691
Abstract
The incision of DNA at apurinic/apyrimidinic sites (AP-sites) by chloro-6-methoxy-2 ((adenyl-9)-11–4,8 diazadecyl )amino-9 acridine (Ade-Z-Acr), a 9-aminoacridine linked to an adenine, at nanomolar concentrations is described. Moreover, this drug, Ade-Z-Acr, is one of the most efficient drugs which cleaves DNA at AP-sites. The high activity is the result of the composition of the drug, since the individual components have no incising activity in the concentration range studied. The termini left by the Ade-Z-Acr mole cule are a 3′deoxyribose and a 5′nucleotide. The termini and the inability of the Ade-Z-Acr to incise DNA with reduced AP-sites suggest that the mechanism of cleavage is u-elimination.This publication has 25 references indexed in Scilit:
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