Atherosclerotic Expansive Remodeled Plaques: A Wolf in Sheep’s Clothing
- 1 December 2002
- journal article
- review article
- Published by S. Karger AG in Journal of Vascular Research
- Vol. 39 (6) , 514-523
- https://doi.org/10.1159/000067204
Abstract
Geometric arterial remodeling is an important determinant of luminal narrowing in atherosclerotic disease. Expansive remodeling retards while constrictive remodeling accelerates luminal narrowing by plaque formation. Cross-sectional as well as follow-up studies revealed that expansive remodeling is associated with adverse cardiovascular events and a vulnerable plaque phenotype. Although the relation between expansive remodeling and plaque vulnerability is associative rather than causal, expansively remodeled plaques should be considered as a wolf in sheep’s clothes. Further understanding of the processes that regulate arterial remodeling and plaque rupture may lead to new strategies to responsibly manipulate these processes for the benefit of patient outcomes.Keywords
This publication has 11 references indexed in Scilit:
- Relationship Between Coronary Artery Remodeling and Plaque VulnerabilityCirculation, 2002
- Morphological Predictors of Arterial Remodeling in Coronary AtherosclerosisCirculation, 2002
- Increased intimal apoptosis in coronary atherosclerotic vessel segments lacking compensatory enlargementJournal of the American College of Cardiology, 2001
- Plaque burden, arterial remodeling and plaque vulnerability: determined by systemic factors?Journal of the American College of Cardiology, 2001
- Furin and membrane type‐1 metalloproteinase mRNA levels and activation of metalloproteinase‐2 are associated with arterial remodelingFEBS Letters, 2001
- Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin siteNature Medicine, 2001
- Preintervention arterial remodeling affects clinical outcome following stenting: an intravascular ultrasound studyJournal of the American College of Cardiology, 2001
- Angioscopic evaluation of atherosclerotic plaques: Validation by histomorphologic analysis and association with stable and unstable coronary syndromesJournal of the American College of Cardiology, 1996
- Contribution of inadequate compensatory enlargement to development of human coronary artery stenosis: An in vivo intravascular ultrasound studyJournal of the American College of Cardiology, 1996
- Arterial remodeling: relation to hemodynamicsCanadian Journal of Physiology and Pharmacology, 1996