Targeting early infection to prevent HIV-1 mucosal transmission
Top Cited Papers
- 1 March 2010
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 464 (7286) , 217-223
- https://doi.org/10.1038/nature08757
Abstract
Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue.Keywords
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