Dissociation constants and structures of zwitterions

Abstract
Dissociation constants of amino-acids in relation to their structures have been discussed in recent years in several publications (Schmidt,et al., 1929; Cohn, 1931; Greenstein, 1931; Melville and Richardson, 1935). A more quantitative treatment seems desirable, however, and such a treatment is attempted in this paper. If in the aliphatic acid R . CH2. COOH one of the hydrogen atoms attached to the α-carbon atom is replaced by the positively charged NH3+group the ionization of the carboxyl group is increased about 280-fold. If substitution occurs in the β- or γ -positions the dissociation constant increases only about 12- or 5-fold respectively.

This publication has 4 references indexed in Scilit: