Urethral Supersensitivity and Occult Urethral Neuropathy

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Abstract
The phenomenon of postural increases in urethral tone in patients with neuropathic bladder dysfunction was investigated and, using the technique of simulated alterations in posture, a humoral response of urethral smooth muscle was demonstrated. Serial measurements of circulating catecholamines have shown that a close correlation exists between the contraction of urethral smooth muscle and the variations in circulating catecholamines brought about as part of cardiovascular homeostasis. Identical urethral responses were recorded in a group of neurologically intact patients who have urethral outflow obstruction. These patients may have an occult urethral neuropathy.