Structural analyses of fibrinogen amyloid fibrils
- 1 January 2007
- journal article
- research article
- Published by Taylor & Francis in Amyloid
- Vol. 14 (3) , 199-203
- https://doi.org/10.1080/13506120701461111
Abstract
Hereditary fibrinogen amyloidosis is characterized by deposition of amyloid fibrils in renal glomeruli. The subunit protein of the amyloid fibrils is a proteolytic fragment of the fibrinogen Aα-chain. To investigate the structure of fibrinogen amyloid, fibrils were extracted from the tissues of a patient and studied by X-ray fiber diffraction and electron microscopy. We have carried out a full structural characterization of amyloid fibrils taken from disease tissue. These studies revealed that ex vivo fibrinogen amyloid fibrils have a cross-β structure similar to other chemical types of amyloid fibrils.Keywords
This publication has 24 references indexed in Scilit:
- Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid FibrilsScience, 2005
- Crystal Structure of Native Chicken Fibrinogen at 2.7 Å Resolution,Biochemistry, 2001
- Curative hepatorenal transplantation in systemic amyloidosis caused by the Glu526Val fibrinogen α‐chain variant in an English familyQJM: An International Journal of Medicine, 2000
- Fibrinogen Act chain mutation (Arg554 Leu) associated with hereditary renal amyloidosis in a French familyAmyloid, 1998
- Common core structure of amyloid fibrils by synchrotron X-ray diffraction 1 1Edited by F. E. CohenJournal of Molecular Biology, 1997
- The molecular basis of renal amyloidosis in Irish-American and Polish-Canadian kindredsQJM: An International Journal of Medicine, 1996
- Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helixStructure, 1996
- Structural studies on FAP fibrils: removal of contaminants is essential for the interpretation of X-ray dataAmyloid, 1995
- Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.Journal of Clinical Investigation, 1993
- HIGH-RESOLUTION ELECTRON MICROSCOPIC ANALYSIS OF THE AMYLOID FIBRILThe Journal of cell biology, 1967