Teased fibre study of early nerve lesions in leprosy and in contacts, with electrophysiological correlates.

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Abstract
A teased fiber technique was used to study [by light microscopy] 19 biopsies of the index finger branch of the radial cutaneous nerve of leprosy patients and contacts. These were compared with 4 normal nerves. Five nerves were from patients with preclinical nerve lesions, 5 from leprosy patients with minimal sensory nerve impairment and 5 from contacts of lepromatous leprosy. The extent of demyelination in preclinical nerve lesions in leprosy and in contacts of leprosy was recorded. The usefulness of nerve conduction velocity studies in early leprosy patients and in contacts was discussed.