Choline acetyltransferase- and peptide immunoreactivity of submucous neurons in the small intestine of the guinea-pig
- 1 August 1984
- journal article
- research article
- Published by Springer Nature in Cell and tissue research
- Vol. 237 (2) , 329-336
- https://doi.org/10.1007/bf00217152
Abstract
Summary The peptides cholecystokinin (CCK), neuropeptide Y (NPY), somatostatin (SOM), substance P (SP) and vasoactive intestinal peptide (VIP), and the synthesizing enzyme for acetylcholine, choline acetyltransferase (ChAT) were localized immunohistochemically in nerve cell bodies of the submucous ganglia in the small intestine of the guinea-pig. VIP-like immunoreactivity was found in 45% of submucous neurons. ChAT immunoreactivity was observed in a separate group of nerve cells, which made up 54% of the total population. There were three subsets of neurons immunoreactive for ChAT: (1) ChAT neurons that also contained immunoreactivity for each of the peptides CCK, SOM and NPY, representing 29% of all submucous neurons; (2) ChAT neurons that also contained SP-like immunoreactivity, representing 11% of all submucous neurons, and (3) ChAT cells that did not contain any detectable amount of the peptides that were localized in this study.Keywords
This publication has 30 references indexed in Scilit:
- Somatostatin is present in a subpopulation of noradrenergic nerve fibres supplying the intestineNeuroscience, 1984
- Neurones localized with antibodies against choline acetyltransferase in the enteric nervous systemNeuroscience Letters, 1983
- Demonstration of carboxyl-terminal PP-like peptides in endocrine cells and nervesPeptides, 1981
- Development of region-specific antisera for the C-terminal tetrapeptide of gastrin/cholecystokinin and their use in studies of immunoreactive forms of cholecystokinin in rat brainNeurochemistry International, 1981
- The fine structure of the submucous plexus of the guinea-pig ileum. II. Description and analysis of vesiculated nerve profilesJournal of Neurocytology, 1981
- The fine structure of the submucous plexus of the guinea-pig ileum. I. The ganglia, neurons, Schwann cells and neuropilJournal of Neurocytology, 1981
- Immunohistochemical support for three putative transmitters in one neuron: Coexistence of 5-hydroxytryptamine, substance p- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cordNeuroscience, 1981
- Substance P Activity in the Bullfrog Retina: Localization and Identification in Several Vertebrate SpeciesScience, 1981
- Coexistence of an avian pancreatic polypeptide (APP) immunoreactive substance and catecholamines in some peripheral and central neuronsActa Physiologica Scandinavica, 1980
- Evidence that some intrinsic neurons of the intestine contain somatostatinNeuroscience Letters, 1977