The Distribution and Excretion of Non-Biodegradable Anionic Surfactants
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 8 (3) , 145-155
- https://doi.org/10.3109/00498257809060393
Abstract
1. The metabolism of potassium 10-undecenyl [3S]sulphate and potassium 10-phenyldecyl [35S]sulphate was investigated in the rat. 2. The major route for elimination of radioactivity following potassium 10-undecenyl [35S]sulphate administration was urinary. With 10-phenyldecyl [35S]sulphate the major route of elimination was biliary. 3. Whole-body radioautography and isolated liver perfusion experiments established that both esters were concentrated in the liver, the major organ of metabolism. 4. Neither surfactant was degraded to short-chain anionic derivatives but both compounds were extensively metabolized.This publication has 15 references indexed in Scilit:
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