Release of gastrin from the skeletal muscles and from the antral mucosa in cats induced by sulfonuric drugs

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Abstract
Apparently sulfonuric drugs release gastrin both from peripheral nerves in striated muscles and from endocrine-like cells in the gastrointestinal tract. Gastrin appears in perfusates of extirpated cat legs after administration of tolbutamide or glibenclamide (5-50 mg/kg or 5-500 .mu.g/kg perfused tissue, respectively) to the perfusion medium. Gastrin is released into the portal vein of cats after i.v. administration of glibenclamide (5-50 .mu.g/kg). As sulfonuric drugs release insulin from .beta.-cells in the pancreas and gastrin from gastrin producing cells in the stomach and from nerve fibers in the skeletal muscles, apparently sulfonuric drugs have more widespread effects than previously assumed. Possible consequences of the drug induced release of peptides from peripheral nerves and of the release of gastrin from the gastrointestinal tract are discussed.