Some thoughts on the one-sided and two-sided tests
- 1 January 1991
- journal article
- review article
- Published by Taylor & Francis in Journal of Biopharmaceutical Statistics
- Vol. 1 (1) , 139-150
- https://doi.org/10.1080/10543409108835011
Abstract
This paper addresses some scientific and regulatory perspectives, insightful regulatory experiences, academic views, and current practices pertinent to one-sided and two-sided tests within the framework of clinical trials designed for specific diseases and drugs. It makes compelling points in favor of applying a two-sided test under a wide variety of situations. Additionally, it discusses situations where one may reasonably argue for use of a one-sided test and concludes by suggesting the use of two-sided tests in controversial situations.Keywords
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