NEUTROPHIL CHEMOTACTIC ACTIVITY AND HISTAMINE IN ATOPIC AND NONATOPIC SUBJECTS AFTER EXERCISE-INDUCED ASTHMA

Abstract
Seven atopic and 6 nonatopic [human] asthmatics with exercise-induced asthma were subjected to a treadmill exercise task. After this procedure, both groups had elevations in the concentrations of plasma histamine and serum high MW neutrophil chemotactic activity (as assessed by Sephadex G-200 chromatography). Release of mast-cell-associated mediators can be independent of the atopic state.