Elution of antinuclear factor from renal lesions of NZB-NZW mice.
- 1 September 1968
- journal article
- Vol. 3 (7) , 665-9
Abstract
Immunoglobulins could be eluted from the glomerular lesions of adult NZB/NZW mice by treatment with acid citrate buffer (pH 3·4). Antinuclear activity was detected in the eluates obtained from homogenates of the kidneys of four out of six mice and from one of two glomerular preparations from two other mice. It is suggested that ANF, as a component of circulating antigen–antibody complexes trapped in the glomeruli, may play a pathogenic role in the development of the glomerular lesions of NZB/NZW mice.This publication has 9 references indexed in Scilit:
- Antinuclear factor in NZB-NZW mice: incidence and in vitro effects.1968
- PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NZB/W MICEThe Journal of Experimental Medicine, 1968
- GLOMERULAR LESIONS IN NZB/NZW MICE - ELECTRON MICROSCOPIC STUDY OF DEVELOPMENT1968
- Autologous Immune-Complex Pathogenesis of Experimental Allergic GlomerulonephritisScience, 1967
- DEVELOPMENT OF RENAL LESIONS IN NZB/NZW MICE IMMUNOHISTOLOGICAL STUDIES1967
- PLASMA PROTEINS IN GLOMERULAR LESIONS OF NZB/NZW MICE1966
- Renal Immunofluorescence in NZB/NZW MiceNature, 1964
- Isolation of Antibody-like Gammaglobulin from Lupus GlomeruliBMJ, 1962
- Direct evidence for the antigenicity of the glomeruli in the production of nephrotoxic serums.1950