STUDIES OF 17-HYDROXYCORTICOSTEROIDS

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Abstract
An ACTH-17-hydroxycorticosteroid response test is described as a measure of adrenal cortical function in which the change in plasma concentrations of 17-hydroxycorticosteroids in response to the intramuscular injection of 25 I.U. ACTH is determined. The limitations of this test are discussed and it is compared with other tests of adrenal cortical function. No correlation is seen between the magnitude of steroid elevation and of eosinopenia in response to ACTH. These data suggest that the ACTH-induced eosinopenia is not mediated by elevations in the circulating concentrations of 17-hydroxycorticosteroids. Although this test might be improved by modifying the ACTH dose or route of ACTH administration, the direct measurement of alterations in circulating concentrations of 17-hydroxycorticosteroids probably represents the most practical approach to evaluation of adrenal cortical responsiveness.

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