Effects of the selective 5‐HT1Bagonist, CGS 12066B, on sleep/waking stages and EEG power spectrum in rats
- 1 June 1994
- journal article
- Published by Wiley in Journal of Sleep Research
- Vol. 3 (2) , 97-105
- https://doi.org/10.1111/j.1365-2869.1994.tb00112.x
Abstract
SUMMARY Sleep/waking stages and EEG power spectra were studied in rats for 8 h following intraperitoneal administration of CGS 12066B, a selective 5‐HT1Bagonist. Waking was increased and rapid eye movement (REM) sleep decreased in a dose‐dependent manner. Total slow‐wave sleep (TSWS) was reduced, but only in the first 2 h period. The latencies to REM sleep and stable sleep were increased dose‐dependently. The drug also induced profound behavioural changes that may account for some of the sleep/waking changes. EEG power densities in waking and TSWS were reduced dose‐dependently from 7 to 20 Hz after CGS 12066B, suggesting a tendency towards general deactivation. The increase in waking together with a general deactivation suggest complex effects of CGS 12066B on the sleep/waking axis.Keywords
This publication has 44 references indexed in Scilit:
- Functional activity of 5‐HT2receptors in the modulation of the sleep/wakefulness statesJournal of Sleep Research, 1992
- Are other 5‐HT receptors besides 5‐HT1Aand 5‐HT2involved in the regulation of sleep and wakefulness?Journal of Sleep Research, 1992
- The 5-HT1A antagonist (−)-alprenolol fails to modify sleep or zimeldine-induced sleep-waking effects in ratsPharmacology Biochemistry and Behavior, 1992
- Behavioural evidence for functional interactions between 5‐HT‐receptor subtypes in rats and miceBritish Journal of Pharmacology, 1990
- Effects of zimeldine, a selective 5-HT reuptake inhibitor, combined with ritanserin, a selective 5-HT2 antagonist, on waking and sleep stages in ratsBehavioural Brain Research, 1990
- Effects of seganserin, a 5-HT2 antagonist, and temazepam on human sleepsstages and EEG power spectraEuropean Journal of Pharmacology, 1989
- Effect of ritanserin on sleep stages and sleep EEG in the ratEuropean Journal of Pharmacology, 1988
- Differential enhancement of rapid eye movement sleep signs in the cat: a comparison of microinjection of the cholinergic agonist carbachol and the β-adrenergic antagonist propranolol on pontogeniculo-occipital wave clustersBrain Research, 1988
- Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamineNeuropharmacology, 1986
- Single unit recordings in the nuclei raphe dorsalis and magnus during the sleep-waking cycle of semi-chronic prepared catsNeuroscience Letters, 1981