Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction
Open Access
- 15 February 2004
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 18 (4) , 381-386
- https://doi.org/10.1101/gad.1166904
Abstract
Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) and Nemo-like kinase (NLK) function in Xenopus, Drosophila, and Caenorhabditis elegans development. Here we report that serine phosphorylation of STAT3 induced by TAK1-NLK cascade is essential for TGF-β-mediated mesoderm induction in Xenopus embryo. Depletion of TAK1, NLK, or STAT3 blocks TGF-β-mediated mesoderm induction. Coexpression of NLK and STAT3 induces mesoderm by a mechanism that requires serine phosphorylation of STAT3. Activin activates NLK, which in turn directly phosphorylates STAT3. Moreover, depletion of either TAK1 or NLK inhibits endogenous serine phosphorylation of STAT3. These results provide the first evidence that TAK1-NLK-STAT3 cascade participates in TGF-β-mediated mesoderm induction.Keywords
This publication has 32 references indexed in Scilit:
- Negative regulation of Wnt signalling by HMG2L1, a novel NLK‐binding proteinGenes to Cells, 2003
- Involvement of NLK and Sox11 in neural induction in Xenopus developmentGenes to Cells, 2002
- Xwnt11and the regulation of gastrulation inXenopusPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2000
- Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptorsOncogene, 2000
- Stat3 as an OncogenePublished by Elsevier ,1999
- Mads and Smads in TGFβ signallingCurrent Opinion in Cell Biology, 1998
- STATs and Gene RegulationScience, 1997
- The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP PhaseScience, 1996
- TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal TransductionScience, 1996
- Processed Vg1 protein is an axial mesoderm inducer in xenopusCell, 1993