Early Permeability Effects of Estradiol on Castrate Rat Uterus.

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Abstract
The influence of estradiol-17[beta] on distribution of certain non-metabolizable sugars, a "non-utilizable" amino acid ([alpha]-aminoisobutyrate), and Na22 in uterus of functionally nephrectoimzed, castrate rats was examined. Substances (inulin, sucrose, and Na22), which are confined to extracellular water in most tissues, appear to enter uterine cells, and distribute in volumes ranging from 58 to 76% of the total water of uterine tissue, exclusive of luminal fluid. D-xylose-1-C14, in the absence of estradiol, distributes in almost all of the water of uterus, and estradiol has no effect on uterine permeability to D-xylose. [alpha]-Aminoisobutyrate is accumulated in excess of the external concentration, and estradiol has no effect at a time when estrogen effects on uterine metabolism of carbohydrate and protein have been observed. Since substrates appear to freely enter uterine cells in the absence of estrogen, it appears that the observed early metabolic changes produced by estrogen are not dependent upon alterations in cell permeability.

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