Observations and an Interpretation of Dose-response Relationships for Cellular Transformation in Terms of Induced (T) Repair

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Abstract
Both radiation-induced lethality and transformation frequency have been observed to plateau or diminish abruptly at relatively low dose levels and then increase with increasing doses, but at a reduced incremental rate. Discontinuities in dose—response relationships are postulated to correspond to the induction of a repair system (‘T’ repair) not functional at lower doses, i.e. below the induction threshold dose (T1). Anomalies (discontinuities) in dose—response relationships and effects of dose fractionation previously noted are qualitatively explained in terms of this model.