Autoantibodies in Malignant Lymphoma of the Thyroid Gland

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Abstract
THE discovery of autoimmune thyroiditis by Witebsky and Rose1 and Roitt and Doniach2 has been confirmed by others3 , 4 and has established the thyroid gland as one of the commonest sites for the development of autoimmunization.Autoimmune hemolytic anemia and other immunologic disturbances are often associated with neoplastic disorders of the lymphoid system such as lymphosarcoma. It has not previously been known that a malignant lymphoma localized in the thyroid gland can produce thyroid autoantibodies.This report reviews the clinical and laboratory data of 6 patients with malignant lymphoma of the thyroid gland and discusses the mechanisms of production and maintenance . . .